Dermatology
What is Rejuran? The secret to Korean celebrity skin
2026-04-10

Rejuran Healer is at the center of the "dewy skin" and "inner glow" trends frequently seen on social media. Why do people keep seeking it out despite reviews saying it is painful? Take a closer look at everything from the principle of fundamentally regenerating the skin rather than simply plumping it, to its actual effects.
Three-sentence summary
Rejuran Healer is a regenerative treatment that uses salmon-derived PN (Polynucleotide) ingredients to help the skin improve on its own .
You must receive the procedure 3 to 4 times at intervals of 2 to 3 weeks . Although there is pain, the skin improves over time.
Since the results vary depending on the practitioner's experience and skill, it is important to choose a verified hospital.
Table of Contents for this Content
Mechanism of Action and Characteristics of Rejuran
Suitable targets and timing of effect onset
Causes of Pain and Alternatives
Reactions and side effects after the procedure
Price Range and Hospital Selection Criteria
1. Mechanism of Action and Characteristics of Rejuran

Rejuran is not just a simple moisturizing injection, but a skin regeneration procedure . Its key ingredient , PN (Polynucleotide) , is derived from salmon and acts directly on the dermis layer of the skin to induce fundamental improvement.
Key difference: Not an "injection procedure" like fillers, but a "procedure that makes the skin improve on its own."
Key effects of Rejuran
Repair of damaged skin: Acts deep within the dermis to promote skin regeneration.
Promotes collagen production: Improves natural elasticity
Strengthening the skin barrier: Increased resistance to external stimuli
Improvement of fine lines: Smoothing skin surface texture
2. Suitable Targets and Timing of Effect Onset
If you have these concerns, consider Rejuran.
When skin has become thin and sensitive: Skin damage caused by excessive care
When skin is fatigued from frequent laser treatments: A condition requiring recovery and soothing.
Lack of radiance even after makeup: Reduced moisture retention in the skin
If you have a photoshoot or an important event coming up: Natural skin improvement is needed
If you want to look naturally younger: Natural-looking anti-aging effect
In particular, the reason celebrities, influencers, and models consistently receive this treatment is also due to these natural skin-improving effects.
Timing of onset and duration of effect
Session 1: Started feeling improvement in skin texture
2nd~3rd session: Significant improvement in hydration and elasticity felt
Sessions 3–4: People around me started saying my skin looked better.
The effect lasts for about 2 to 6 months , and it is generally recommended to repeat the procedure 3 to 4 times at intervals of 2 to 3 weeks .
3. Causes of Pain and Alternatives

Why does it hurt so much?
The reason Rejuran is painful is clear. It is because it involves injecting the skin directly about 70 to 80 times . Unlike Botox, which treats only a few spots, this method involves densely puncturing the entire skin, so you may still feel pain even if you apply anesthetic cream.
If you are worried about pain: Rejuran HB
Rejuran HB is a version of regular Rejuran with the following ingredients added:
Hyaluronic acid: Enhanced moisturizing effect
Lidocaine: An anesthetic component that relieves pain
It can reduce pain and increase hydration, but it costs more than regular Rejuran.
4. Reactions and Side Effects After the Procedure

What if your face becomes bumpy after the procedure?
This is a point that often surprises people, but it is a normal reaction . It is a phenomenon where the injected area temporarily rises like an embossing:
Recovery time: Usually disappears naturally within 24 to 48 hours
Return to daily routine: Makeup is also possible starting the next day.
Note: This phenomenon is close to a "sign that it has worked well"!
Side Effects and Precautions
Rejuran is known as a relatively safe procedure. It is a biocompatible material that decomposes within the body, and cases of serious side effects are very rare.
However, since this is an injection procedure, the following reactions may occur:
Bruising and Swelling: Temporary Reactions at the Injection Site
Itching and heat sensation: Phenomena occurring during the skin regeneration process
Most people recover naturally within 1 to 2 weeks .
5. Price Range and Hospital Selection Criteria
Price Information
Procedure range | volume | price range |
|---|---|---|
The whole face | Based on 2cc | Approximately 300,000 to 400,000 won per session |
There are differences depending on the hospital, procedure, and medical staff.
The important thing is "where you receive it"
Even with the same Rejuran, the reason the results differ depends on who administers it, how it is administered, and how evenly it is done .
Procedure Method: Difference between Manual Injection vs. Injector Method
Depth Adjustment: Customized treatment based on skin condition
Infusion Density: Designing Appropriate Infusion Volumes by Site
Points to Check When Choosing a Hospital
Real Reviews: Real experiences, not promotional reviews
Procedure Experience: A clinic with extensive experience in Rejuran procedures
Experience with Foreigners: Experience with treatments on various skin types
Medical Staff Expertise: Board Certified Dermatologist Status and Experience
Advantages of using K-DOC: You can select only verified hospitals, compare based on actual reviews, and handle everything from consultation to booking in one go, focusing on hospitals with extensive experience with foreign patients.
Rejuran is a procedure that creates skin that improves over time rather than providing an immediate "glow." That is why many people receive it consistently rather than just once. If you are looking for natural and fundamental skin improvement, even if it involves some pain, it is an option well worth considering.


